Rebecca Stauß
- University Medical Center Mainz
- Thomas Hofmann lab
- Project 3. A role for FLASH/Casp8AP2 in R-loop regulation.
- German
“R-loops captured my interest due to their significant role in transcription and their potential to cause DNA damage if misregulated. This balance makes them a crucial field of study in understanding genome stability.”
the role of FLASH/Casp8AP2 depletion in R-loop formation and its downstream effects on DNA damage. Initial findings showed that depletion of FLASH in mammalian cells induces g-H2AX foci, a marker of DNA breaks. The project aims to uncover the mechanisms by which FLASH depletion induces R-loops, investigate whether these R-loops activate DNA damage checkpoint signaling, and determine the importance of the R-loop-induced DNA damage response for S-phase accumulation. Further, the study will identify where in the genome R-loops form and explore the biological consequences of increased R-loops.
Playing Boule, cooking and electronic music.
2019 – 2024: Johann Wolfgang Goethe University of Frankfurt, Frankfurt am Main, Germany.
2016 – 2019: Johannes Gutenberg University of Mainz, Mainz, Germany.