Fatmanur Tiryaki

“4R RTG provides me with the perfect media where I can work on my dream project in a vigorous environment with a great group of researchers.”

FUS is a DNA/RNA-binding protein with great pathological relevance in neurodegenerative diseases. Multiple evidence suggests that FUS is recruited to DNA damage sites upon UV irradiation and suppresses transcription-associated DNA damage and R-loop accumulation. My project aims to unravel the molecular mechanisms involved in FUS-mediated R-loop suppression and to understand the recruitment of FUS to DNA damage sites using in vitro and cellular systems.

Hiking, bouldering, dancing, painting

2018-2021: MSc in Molecular Biology and Genetics at Koç University in Istanbul, Turkey

2012-2018: BSc in Molecular Biology and Genetics at Boğaziçi University in Istanbul, Turkey


  1. Tiryaki F, Deretic J, Firat-Karalar EN. ENKD1 is a centrosomal and ciliary microtubule-associated protein important for primary cilium content regulation. FEBS J. 2022 Jul;289(13):3789-3812. doi: 10.1111/febs.16367. Epub 2022 Feb 3. PMID: 35072334.

  2. Aydın M, Uysallı Y, Özgönül E, Morova B, Tiryaki F, Firat-Karalar EN, Doğan B, Kiraz A. An LED-Based structured illumination microscope using a digital micromirror device and GPU accelerated image reconstruction. PLoS One. 2022 Sep 9;17(9):e0273990. doi: 10.1371/journal.pone.0273990. PMID: 36084054; PMCID: PMC9462783.