Lukas Marian Graf
- Institute of Molecular Biology Mainz
- Petra Beli lab
- Project 2. Regulatory interplay between R-loops and transcription
- German
“R-loops have been shown to be important in several cellular processes and dysregulation of R-loops was linked to multiple human diseases. However, there is still a lot to be discovered about the physiological roles of R-loops and their regulation. I am therefore excited to work in such a rapidly evolving field of research.”
I want to explore the regulation of nuclear and cytoplasmic RNA-DNA hybrids. To this end, I am going to use proteomics approaches to study R-loops as well as R-loop-derived RNA-DNA hybrids. I further want to investigate the role of these RNA-DNA hybrids in inflammatory signaling using RNA-DNA proximity proteomics.
I enjoy trekking, bouldering, and amateur astronomy.
2021 – 2023: Technical University of Darmstadt.
2017 – 2021: Johannes Gutenberg University of Mainz.