João Marques
- Institute of Molecular Biology Mainz
- René Ketting lab
- Project 7. R-loop function in nuclear RNA interference
- Portuguese
“As an enthusiast of genome regulatory mechanisms, a program focused on R-loops,such as the 4R was pivotal for advancing my understanding of genome stability and gene expression regulation.”
small RNA-guided gene regulatory pathways, utilizing Argonaute proteins, are a conserved mechanism for controlling gene expression and genome stability. In organisms such as C. elegans, the Argonaute protein HRDE-1 triggers H3K9 trimethylation at specific loci, utilizing inherited small RNAs to induce gene silencing. This project aims to elucidate the molecular role of the R-loop resolving protein AQR (EMB-4 in C.elegans) in nuclear RNAi, exploring its involvement in the intricate interplay between small RNA pathways and chromatin modifications.
I do road cycling.
2021 – 2023: Functional biology and functional biotechnology of plants, University of Porto.
2016 – 2020: Nutrition Sciences, Fernando Pessoa University.