Gutenberg Workshop RNase H 2024: Structures, Functions and Disorders

The 17th RNase H meeting, organized as a Gutenberg Workshop “RNase H 2024: Structure, Functions and Disorders”, will be in Ingelheim am Rhein, Germany. It will cover everything about RNases H: substrates, biochemistry, structures, genetics, and diseases involving RNases H. This meeting has been held every two years since 1990 (except for 2020, due to COVID), with Japan, USA, Canada, Scotland, France, and Poland hosting.

Two RNases H are found in most organisms and these nucleases have important roles relating to DNA replication, DNA damage prevention and DNA repair. Humans with mutations in RNASEH1 exhibit a severe mitochondrial myopathy, whereas mutations in any of the subunits of the heterotrimeric RNase H2 cause a severely disabling interferonopathy, Aicardi-Goutières Syndrome. Retroviruses, including AIDS-HIV, encode a reverse transcriptase that has DNA polymerase and RNase H activity, both of which directly participate in replication of the viral DNA.

Many of the major discoveries on RNases H, composition, structures, substrates and functions, were first reported at one of these meetings. Studies presented at these meetings used model organisms, including prokaryotes, fungi, plants, viruses, animals and humans, establishing abundant properties and roles for RNases H.

Join us in 2024 to hear about new and exciting results!

Information About the Meeting:

Scientific organizers

  • Robert Crouch – NIH, Bethesda, USA
  • Susana Cerritelli – NIH, Bethesda, USA
  • Andrew Jackson – The University of Edinburgh, Edinburgh, UK
  • Martin Reijns – The University of Edinburgh, Edinburgh, UK
  • Brian Luke – Johannes Gutenberg University of Mainz, Mainz, Germany

Invited Speakers

  • Petra Beli – Johannes Gutenberg University of Mainz, Mainz, Germany
  • Alexander Bishop – University of Texas, San Antonio, USA
  • Andrei Chabes – University of Umeå, Umeå, Sweden
  • Frédéric Chédin – The University of California, Davis, USA
  • Aziz el Hage – The University of Edinburgh, Edinburgh, UK
  • Natalia Gromak – University of Oxford, Oxford, UK
  • Pablo Huertas – CABIMER, Seville, Spain
  • Andrei Kuzminov – The University of Illinois, Urbana, USA
  • Houra Merrikh – Vanderbilt School of Medicine, Nashville, USA
  • Marcin Nowotny – IIMCB, Warsaw, Poland
  • Philippe Pasero – University of Montpellier, Montpellier, France
  • Paulina Wanrooij – University of Umeå, Umeå, Sweden
  • Jessica Williams – NIH, Durham, USA

Scientific Director of the Gutenberg Workshops in the Life Sciences:

  • Peter Baumann – Johannes Gutenberg University of Mainz, Mainz, Germany

Conference Registration Overview:

Registration for this meeting is open from the 12th of February 2024 to the 15th of July 2024. Your registration fee will cover:

  • Coffee breaks and snacks;
  • Lunch;
  • Dinners;
  • Social event;
  • Scientific sessions and abstract book.

The registration fees are:

  • Students – 250 Euros
  • Postdocs and Principal Investigators – 300 Euros

Information on Abstract Submission:

Please submit your abstract by the 1st of September 2024 to Robert Crouch and 4R RTG coordinator with subject line ABSTRACT: RNase H 2024, submitter_surname.

Abstracts must be a Word document, using Times Roman 12 point font, formatted for the European A4 document size. All abstracts will be accepted for an oral presentation. We kindly ask you to use the template provided below.

Information on Accommodation:

We recommend booking a room in Ingelheim am Rhein using the Keyword “Gutenberg Workshops” to book a room at a conference price (appx. 100 to 120 Euros a night, depending on a room). The Keyword “Gutenberg Workshops” is valid in the following hotels:

The Wasem Weinhotel is located right next to the conference venue, while the IBB Ingelheim is located at a walkable distance from the venue, 2 kilometers away. You can take buses 640 (direction Oppenheim), 625 (direction Bahnhof), 654 (direction Hauptbahnhof Mainz) and exit at stop “Ober-Ingelheim Marktplatz”, an 8 minute walk from Wasem.

Please note that your booking is on a self-pay basis, as the hotel stay is not included in the conference fee.

Travel Details:

Conference Venue

Wasem Kloster Engelthal

Edelgasse 15, 55128

Ingelheim am Rhein


Travel from Frankfurt Airport (FRA)

You have the option to catch either the RE3 train bound for Saarbrücken or the RE2 train headed to Koblenz from Frankfurt airport. Disembark at Ingelheim Bahnhof (Ingelheim train station), approximately 40 minutes into the journey. You can purchase tickets from a ticket machine at the airport or on the Deutsche Bahn’s website, where you can also plan your journey.

Once you reach Ingelheim Bahnhof (Ingelheim train station), you can take the bus 640 (direction Oppenheim), 625 (direction Bahnhof), 654 (direction Hauptbahnhof Mainz) and exit at stop “Ober-Ingelheim Marktplatz”, an 8 minute walk from Wasem.

Workshop Organizers:

Gutenberg Workshops
in Life Sciences

Gutenberg Workshops / BioCenter 1 Hanns-Dieter-Hüsch-Weg 15 • 55128 Mainz • +49 (0) 6131 3922800
Peter Baumann is the Scientific Director of GW in the life sciences

4R: R-loop Regulation in Robustness and Resilience

BioCenter 1 Hanns-Dieter-Hüsch-Weg 15 • 55128 Mainz •
+49 (0) 6131 3930986
Olga Vydzhak is the RNase H 2024 organizer
from the 4R RTG

Centre for Healthy Ageing