Maxin Bakalo
- Institute of Molecular Biology Mainz
- Roopesh Anand lab
- Project 15. Investigating the life cycle of RAD51AP1-mediated R-loops
- German
“R-loops play crucial roles in transcription regulation as well as genome instability. I am eager to explore how they are formed and are switched to D-loops for DNA double-strand break repair.”
the formation and resolution of R-loops at telomeres, focusing on the role of RAD51AP1 in Alternative Lengthening of Telomeres (ALT) in cancer cells. I aim to elucidate how RAD51AP1 mediated R-loop formation and its subsequent conversion into D-loops, facilitating DNA break repair through homologous recombination. Employing a combination of bulk biochemistry and single-molecule techniques, my project seeks to unravel the mechanistic details of R-loop dynamics and their implications for telomere maintenance in cancer.
I like reading, hiking, and volunteer work.
2021 – 2024: MSc in Molecular Life Science: Microbiology, Biotechnology and Biochemistry, Georg-August University Göttingen, Germany.
2018 – 2021: BSc in Molecular Biology, Johannes Gutenberg University Mainz, Germany.