Chitra Roy
- Institute of Molecular Biology Mainz
- Helle Ulrich lab
- Project 5. Functional analysis of R-loops and RNA:DNA hybrids associated with DNA lesions
- Indian
“My research on circular RNAs sparked my interest in their ability to form circ-R-loops, which led me to explore the broader R-loop landscape and their regulatory roles in genome stability.”
Single-strand breaks (SSBs) in the DNA are by far the most common lesions and if left unrepaired, they can escalate to severe DNA damage. To better understand their origins and genomic distribution, it is essential to map them in an unbiased way- a challenge that has limited progress in this field. Therefore, my PhD project leverages GLOE-Seq to map SSBs in nucleotide resolution, in conjunction with genome-wide-R-loop mapping tools to understand how unscheduled, pathological or regulatory R-loops contribute to genome instability. I will investigate the regulatory context of R-loop associated DNA damage.
I enjoy reading books, watching movies and cooking.
2019 – 2021: Biotechnology, University of Calcutta, India.
2016 – 2019: Microbiology, University of Calcutta, India.
Publications
Das, S., Laha, S., Roy, C. et al. Circular RNA deregulation drives psoriasis pathogenesis via interfering with canonical microRNAs. Arch Dermatol Res 316, 442 (2024). Link to the paper.