Sebastian Gruber
- Johannes Gutenberg University of Mainz
- Dorothee Dormann lab
- Project 6. R-loop regulation by neurodegeneration-linked DNA/RNA-binding proteins FUS and TDP-43
- German and Austrian
“I chose R-loops because they’re unpredictable – and with TDP-43 involved, it’s like adding a wildcard to a molecular drama that keeps rewriting the script.”
TDP-43, a RNA/DNA-binding protein that plays a crucial role in different neurodegenerative diseases. It is known that TDP-43 is important for the DNA damage repair and also that it is needed for the repression of R-loops. My project aims to find out what molecular mechanism is behind the suppression of R-loops with TDP-43 involved and how TDP-43 gets recruited on DNA-damage sites.
I like gardening, jogging, video games.
2021 – 2025: M.Ed. in Chemistry and Biology at the Johannes Gutenberg University in Mainz, Germany.
2018 – 2021: B.Ed. in Chemistry and Biology at the Johannes Gutenberg University in Mainz, Germany.