Fatima Alkafri
- Institute of Molecular Biology Mainz
- Petra Beli lab
- Project 2. Regulatory interplay between R-loops and transcription
- Palestinian
“The dual nature of R-loops as regulators of gene expression and potential threats to genome stability makes them an intriguing subject of study. Despite their importance and links to several pathologies, much remains unknown about how cells sense, regulate, and resolve these structures.”
how cells detect and respond to DNA torsional stress, a major consequence of essential DNA-templated processes and a source of R-loop biogenesis. Using the bacterial DNA stress sensor GapR fused to the proximity labelling enzyme TurboID, I aim to identify and functionally characterize proteins that are recruited to sites of positive supercoiling in human cells. This would contribute to understanding how DNA topology, chromatin architecture, and genome maintenance are functionally connected.
I enjoy cooking, nature walks, coffee with friends.
2023 – 2025: MSc in Molecular Biology, University of Göttingen.
2019 – 2023: BSc in Biotechnology, University of Sharjah.